Comparison of Phenotypic and Genotypic Features in Human Primary Large Bowel Carcinomas and Lymph Node Metastases

摘要: Abstract In order to test the contention that metastasis is a selective process and therefore metastases might show more restricted pattern of phenotypic genotypic characteristics than primary tumors, we compared expression carcinoembryonic antigen, Ca 19-9, secretory component, serotonin, mucin production as well flow cytometric data on DNA content percentage S-phase cells in 87 large bowel carcinomas their lymph node metastases. majority cases tumors were largely identical with regard examined features. discrepant cases, however, did not invariably indicating high differentiational plasticity metastatic colorectal cancer cells. contrast, number discrepancies observed. We conclude cannot be used study pathogenesis metastasis. Genotypic studies, suggest lymphogenic may event.