An alpha-lipoic acid-decursinol hybrid compound attenuates lipopolysaccharide-mediated inflammation in BV2 and RAW264.7 cells.

摘要: In this study, the anti-inflammatory effects of α-lipoic acid (LA) and decursinol (Dec) hybrid compound LA-Dec were evaluated compared with its prodrugs, LA Dec. dose-dependently inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) generation in BV2 mouse microglial cells. On other hand, no or mild inhibitory effect was shown by Dec LA, respectively. demonstrated dose-dependent protection from activation-induced cell death LA-Dec, but not individually, LPS-induced increased expressions induced NO synthase (iNOS) cyclooxygenase-2 (COX-2) proteins a dosedependent manner both macrophage, RAW264.7 Furthermore, iNOS, COX-2, interleukin-6, tumor necrosis factor-α, interleukin-1β mRNA cells, whereas same concentration ineffective. Signaling studies that LPS-activated signal transducer activator transcription 3 protein kinase B activation, nuclear factor-kappa mitogen-activated signaling. The data implicate as potential therapeutic agent for inflammatory diseases peripheral central nervous systems. [BMB Reports 2019; 52(8): 508-513].