Low-density lipoprotein and its effect on human blood platelets
作者： I. A. M. Relou , C. M. Hackeng , J.-W. N. Akkerman , E. Malle
DOI: 10.1007/S00018-003-2249-Y
关键词: Platelet activation 、 Lipoprotein 、 Lysophosphatidic acid 、 Internal medicine 、 Low-density lipoprotein 、 Hyperlipidemia 、 Endocrinology 、 Chemistry 、 Platelet 、 Signal transduction 、 Biochemistry 、 LDL receptor
摘要: Events leading to hyperactivity of human blood platelets are accompanied by an enhanced risk atherosclerosis and arterial thrombosis. Lipoprotein disorders affect platelet functions, hypersensitive observed in various stages hyperlipidemia. Low-density lipoprotein (LDL), a circulating complex lipids proteins that is increased hypercholesterolemia, enhances function increases sensitivity several naturally occurring agonists. LDL sensitizes via binding apoB-100 receptor on the membrane transfer membrane. The mediates initiates subsequent intracellular signaling cascades has not yet been identified. Modification native generates platelet-activating particle, this interaction might contribute development atherosclerotic plaque. Lysophosphatidic acid formed upon mild oxidation responsible for activation induced modified particle. Thus, changes functions broad spectrum interactions.
springer.com
sci-hub.se 参考文章(111)
Javier Pedreño, Eva Hurt-Camejo, Olov Wiklund, Lina Badimón, Lluis Masana, Low-density lipoprotein (LDL) binds to a G-protein coupled receptor in human platelets Atherosclerosis. ,vol. 155, pp. 99- 112 ,(2001) , 10.1016/S0021-9150(00)00545-1
D Echevaría-Vázquez, Victor Petrov, Paul Lijnen, Influence of cholesterol-lowering on plasma membrane lipids and function Methods and Findings in Experimental and Clinical Pharmacology. ,vol. 18, pp. 123- 136 ,(1996)
Schrör K, Steinhagen-Thiessen E, Löbel P, Simvastatin reduces platelet thromboxane formation and restores normal platelet sensitivity against prostacyclin in type IIa hypercholesterolemia. Eicosanoids. ,vol. 2, pp. 39- 45 ,(1989)
MJ Broekman, RI Handin, A Derksen, P Cohen, Distribution of phospholipids, fatty acids, and platelet factor 3 activity among subcellular fractions of human platelets. Blood. ,vol. 47, pp. 963- 971 ,(1976) , 10.1182/BLOOD.V47.6.963.BLOODJOURNAL476963
M E Turini, B J Holub, Eicosanoid/thromboxane A2-independent and -dependent generation of lysoplasmenylethanolamine via phospholipase A2 in collagen-stimulated human platelets Biochemical Journal. ,vol. 289, pp. 641- 646 ,(1993) , 10.1042/BJ2890641
A Shmulewitz, J G Brook, M Aviram, Native and modified low-density-lipoprotein interaction with human platelets in normal and homozygous familial-hypercholesterolaemic subjects. Biochemical Journal. ,vol. 224, pp. 13- 20 ,(1984) , 10.1042/BJ2240013
E Koller, F Koller, B R Binder, Purification and identification of the lipoprotein-binding proteins from human blood platelet membrane. Journal of Biological Chemistry. ,vol. 264, pp. 12412- 12418 ,(1989) , 10.1016/S0021-9258(18)63874-8
David Tulasne, Teresa Bori, Steve P. Watson, Regulation of RAS in human platelets. Evidence that activation of RAS is not sufficient to lead to ERK1-2 phosphorylation. FEBS Journal. ,vol. 269, pp. 1511- 1517 ,(2002) , 10.1046/J.1432-1033.2002.02798.X
Susanna Colli, Paola Maderna, Elena Tremoli, Anna Baraldi, Gian Enrico Rovati, Gianfranceschi Gemma, Simonetta Nicosia, Prostacyclin-lipoprotein interactions. Studies on human platelet aggregation and adenylate cyclase. Biochemical Pharmacology. ,vol. 34, pp. 2451- 2457 ,(1985) , 10.1016/0006-2952(85)90525-8
G. Endemann, L.W. Stanton, K.S. Madden, C.M. Bryant, R.T. White, A.A. Protter, CD36 is a receptor for oxidized low density lipoprotein. Journal of Biological Chemistry. ,vol. 268, pp. 11811- 11816 ,(1993) , 10.1016/S0021-9258(19)50272-1