Short-duration transcranial random noise stimulation induces blood oxygenation level dependent response attenuation in the human motor cortex.

摘要: Manipulation of cortical excitability can be experimentally achieved by the application transcranial random noise stimulation (tRNS). TRNS is a novel method non-invasive electrical brain whereby oscillation spectrum applied over cortex. A previous study recently reported that weak 10-min tRNS primary motor cortex (M1) enhances corticospinal both during and after in healthy human brain. Here, blood oxygenation level dependent (BOLD) MRI was used to monitor modulations sensorimotor activity 4-min tRNS. Activation maps for right hand index–thumb finger opposition task were obtained nine subjects sham 1-mA separate sessions. left-hemispheric resulted decrease mean number activated pixels 17%, area. Our results indicate with different durations and/or combination might result outcomes. Application allows an unnoticeable thus painless, selective, reversible change within cortex, its main advantage being direction insensitivity stimulation. also provides qualitatively new way producing interfering plasticity, although, further research required optimise parameters efficacy.