Role of FTO gene polymorphisms in Wilms tumor predisposition: A five-center case-control study.
作者： Guochang Liu , Rui-Xi Hua , Rui-Xi Hua , Wen Fu , Jing He
DOI: 10.1002/JGM.3348
关键词: SNP genotyping 、 Polymorphism (computer science) 、 FTO gene 、 SNP 、 Expression quantitative trait loci 、 Biology 、 Oncology 、 Internal medicine 、 Allele 、 Single-nucleotide polymorphism 、 Wilms' tumor
摘要: BACKGROUND Wilms tumor is the most frequently occurring renal malignancy in pediatrics. The FTO gene exhibits a featured genetic contribution to cancer development. Nonetheless, its single nucleotide polymorphism (SNP) remains unknown. METHODS In present study, 402 patients and 1198 healthy controls were successfully genotyped for SNPs (rs1477196 G>A, rs9939609 T>A, rs7206790 C>G rs8047395 A>G) using TaqMan SNP genotyping assays. Odds ratios (ORs) 95% confidence intervals (CIs), generated from unconditional logistic regression, applied quantify effects of on risk. RESULTS We found that A>G was significantly correlated with an increased risk (GG versus AA/AG: adjusted OR = 1.38, CI = 1.04-1.85, p = 0.027). Carriers 1 1-2 genotypes are more susceptible developing than those without genotypes. Stratified analysis revealed significant relationships certain subgroups. Preliminary functional annotations A allele increases expression levels as determined by quantitative trait locus analysis. CONCLUSIONS study provides evidence may regulate thus confer susceptibility tumor. candidate identified this warrants independent investigation.
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