Genotyping CagA, VacA subtype, IceA1, and BabA of Helicobacter pylori isolates from Korean patients, and their association with gastroduodenal diseases.
作者： Seok Yong Kim , Chan Won Woo , Young Min Lee , Bo Ra Son , Ji Won Kim
DOI: 10.3346/JKMS.2001.16.5.579
关键词: Genotype 、 Biology 、 Helicobacter pylori 、 Genotyping 、 Antrum 、 Polymerase chain reaction 、 Microbiology 、 Gastritis 、 CagA 、 Biopsy
摘要: The genetic status of cagA, vacA subtype, iceA1, and babA, the relationship to gastroduodenal diseases were assessed in Helicobacter pylori isolates Korea. Seventy-six strains H. isolated from antrum corpus 41 adult patients (22 with peptic ulcer 19 gastritis). babA genes by polymerase chain reaction subtypes determined reverse hybridization-line probe assay. positive rates 349-bp 208-bp 97.4%, 96.1%, 84.2%, 36.1%, respectively. s1a, s1b, s1c, s2 variants detected 11.8%, 3.9%, 80.4%, 1.3%, m1 (78.9%) is more prevalent than m2 (5.3%). most common genotype was s1c/m1 (61.9%), 14 (18.4%) contained mixed genotypes a single biopsy specimen. Twenty-one (60%) 35 infected two different genotypes. None s1/m1 associated ulcer. In conclusion, Korea carry genes, reside multiple strains. These do not correlate Korean patients.
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