Activator complexes containing the proteasomal regulatory ATPases S10b (SUG2) and S6 (TBP1) in different tissues and organisms.
作者： Richard Hastings , Gail Walker , Ignacio Eyheralde , Simon Dawson , Michael Billett
关键词: Manduca 、 Proteasome 、 Biology 、 Biochemistry 、 Skeletal muscle 、 Protein subunit 、 Activator (genetics) 、 ATPase 、 Transcription (biology) 、 Manduca sexta
摘要: Each 19S regulator of the 26S proteasome contains six ATPase subunits as well many (>14) non-ATPase protein subunits. The have been detected in other complexes which may regulate transcription and possibly cellular processes. S10b (yeast SUG2 or human p42) S6′ (TBP1) ATPases found an activator complex (modulator) prepared from bovine red cells. We identified partially characterised a similar different tissues (from soluble extracts brain, placenta embryonic kidney cells) insect: is present abdominal intersegmental muscle Manduca sexta. Activation ATP concentration dependent. There no stimulation cell-derived 20S by ruling out 11S preparations. Additionally, cross-species activation occurs: increases activity rat skeletal proteasomes placental similarly muscles Finally, there evidence for complex.
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