A novel stereospecific synthesis of 22-hydroxylated triterpenes and steroids: syntheses of 22R-hydroxylanosterol and 22R-hydroxydesmosterol
作者： Alain Amann , Guy Ourisson , Bang Luu
DOI: 10.1055/S-1987-28048
关键词: Organic chemistry 、 Lanosterol 、 Ylide 、 Diol 、 Chemistry 、 Side chain 、 Triterpene 、 Stereochemistry 、 Stereospecificity 、 Aldehyde 、 Steroid
摘要: 22R-Hydroxylanosterol (10) is prepared from lanosterol (1) with an overall yield of over 30%. The key step the synthesis stereospecific coupling aldehyde 7 arsenic ylide. same reaction used to build side chain 22R-hydroxydesmosterol (14).
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