IN VIVO EVALUATION OF COMBINATION EFFECTS OF CHLOROQUINE WITH CEPHARANTHIN® OR MINOCYCLINE HYDROCHLORIDE AGAINST BLOOD-INDUCED CHLOROQUINE-RESISTANT PLASMODIUM BERGHEI NK 65 INFECTIONS

摘要: The combination effects of chloroquine with Cepharanthin® or minocycline hydrochloride were evaluated against a blood-induced infection chloroquine-resistant P. berghei NK 65 in ICR mice. infected mice an untreated control group showed progressively increasing parasitemia leading to mouse death. A two-day dosage 20 mg base/kg alone produced little effect infection, and all died from day 13 15 parasitemia. four-day 4 mg/kg no antimalarial activity, by 10. 50 slight effect, but 18. Furthermore, given 14 15. Mice plus also 17. On the other hand, treated survived during experiment. All alone, low levels drug administration few subsequent days, then malaria parasites re-increased bloodstream until decreased on 6 could not be detected microscopic examination observation period. This finding strongly suggests that are worthy evaluation human malaria. results clearly demonstrate necessity importance vivo experiments estimating activities drugs.