A review of the influence of mammographic density on breast cancer clinical and pathological phenotype

摘要: It is well established that high mammographic density (MD), when adjusted for age and body mass index, one of the strongest known risk factors breast cancer (BC), also associates with higher incidence interval cancers in screening due to masking early abnormalities. Increasing research being undertaken determine underlying histological biochemical determinants MD their consequences BC pathogenesis, anticipating improved mechanistic insights may lead novel preventative or treatment interventions. At same time, technological advances digital contrast mammography are such validity well-established relationships needs be re-examined this context. With attention old versus new technologies, we conducted a literature review summarise between clinicopathologic features surrounding tissue on mammography, including associations biological inclusive subtype, implications clinical disease course encompassing relapse, progression, response survival. There reasonable evidence support positive (HMD) tumour size, lymph node positivity local relapse absence radiotherapy, but not HMD LVI, regional distant metastasis. Conflicting data exist location, grade, intrinsic receptor status, second primary survival, which need further confirmatory studies. We did identify any hold up involving newer imaging techniques were employed analysis.