White matter alterations in glaucoma and monocular blindness differ outside the visual system.

摘要: The degree to which glaucoma has effects in the brain beyond eye and visual pathways is unclear. To clarify this, we investigated white matter microstructure (WMM) 37 tracts of patients with glaucoma, monocular blindness, controls. We used brainlife.io for reproducibility. White were subdivided into seven categories ranging from those primarily involved vision (the matter) cognition motor control. In tracts, WMM was decreased as measured by fractional anisotropy both blind subjects compared controls, suggesting neurodegeneration due reduced sensory inputs. A test–retest approach validate these results. pattern results different subjects, where properties increased outside This suggests that whereas loss input might promote reorganization early system, such be or absent glaucoma. provide indirect evidence unknown factors limit seen other patient groups following loss.