Depletion of gentamicin and its major components from various tissues of turkeys.
作者： Motti Shem-Tov , Nagy Gabor , Miklos Suth , Peter Kormoczy
DOI: 10.2460/AJVR.2003.64.1234
关键词: Animal science 、 Chromatography 、 Biology 、 Gentamicin Sulfate 、 Gentamicin C1 、 Gentamicin 、 Once daily 、 Kidney
摘要: Objective—To determine tissue depletion profiles for gentamicin and its 3 major components (C1, C1a, C2) in turkeys. Animals—Twenty 10-week-old male Procedure—4 birds were maintained as untreated controls. The remaining treated with sulfate at a dosage of 2 mg/kg, IM, once daily 5 days. Treated euthanatized 45, 60, 75, 90 days (4 each sample time) after the last dose was administered, samples muscle, liver, kidney, skin fat collected. Control on day 45. Concentrations measured by means reversed-phase high-performance liquid chromatography. Results—Total concentration (ie, sum concentrations components) < 100 µg/kg all muscle 45 liver 75. At times, C1 component higher than C1a a...
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