Identification of protein adduction using mass spectrometry: Protein adducts as biomarkers and predictors of toxicity mechanisms.
作者： Xiangkun Yang , Michael G. Bartlett
DOI: 10.1002/RCM.7462
关键词: Xenobiotic 、 Chemistry 、 Biochemistry 、 Mass spectrometry 、 Protein adducts 、 Acetaminophen 、 Toxicology 、 Toxicity 、 Potential biomarkers
摘要: The determination of protein-xenobiotic adducts using mass spectrometry is an emerging area which allows detailed understanding the underlying mechanisms involved in toxicity. These approaches can also be used to reveal potential biomarkers exposure or toxic response. following review covers studies protein resulting from a wide variety xenobiotics including organophosphates, polycyclic aromatic hydrocarbons, acetaminophen, alkylating agents and other related compounds.
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