Community-acquired methicillin-resistant staphylococcus aureus in children with no identified predisposing risk

摘要: Context.—Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections in children have occurred primarily individuals with recognized predisposing risks. Community-acquired MRSA in the absence of identified risk factors been reported infrequently.Objectives.—To determine whether community-acquired children with no risks are increasing and to define the spectrum of disease associated with isolation.Design.—Retrospective review medical records.Patients.—Hospitalized S aureus isolated between August 1988 July 1990 (1988-1990) between 1993 and July 1995 (1993-1995).Setting.—The University Chicago Children's Hospital.Main Outcome Measures.—Prevalence over time, infecting vs colonizing isolates, for disease.Results.—The number hospitalized disease increased from 8 1988-1990 35 1993-1995. Moreover, prevalence of without increased 10 per 100000 admissions 259 100000 admissions 1993-1995 (P<.001), a greater proportion isolates produced clinical infection. The clinical syndromes without identified were similar those methicillin-susceptible aureus. Notably, 7 (70%) MRSA isolates obtained an nonsusceptible to at least 2 drugs, compared only 6 (24%) 25 from children (P=.02).Conclusions.—These findings demonstrate that prevalence community-acquired MRSA among is increasing.