In vitro effect of clinical propofol concentrations on platelet aggregation.
作者： Hye Gyo Chung , Soohyun A. Myung , Ho Sung Son , Yun Hee Kim , Jin Namgung
DOI: 10.1111/J.1525-1594.2012.01553.X
关键词: Adenosine 、 Platelet 、 Incubation period 、 Epinephrine 、 Propofol 、 Intensive care 、 Incubation 、 Anesthesia 、 Medicine 、 Sedation
摘要: The inhibitory effect of propofol on platelet aggregation remains unclear, and studies the subject disagree. Furthermore, although infusions are widely used for general anesthesia as sedatives patients in intensive care units, little information is available its concentration- time-related effects aggregation. Here, authors investigated vitro propofol, at concentrations required sedation anesthesia, after 1, 2, or 3 h. Blood from healthy volunteers (n = 9) was incubated plasma 0, 4, 10 μg/mL a water bath 37°C. Platelet measured using function analyzer (PFA-100) 3 h incubation. Times to occlude collagen/epinephrine (CEPI) collagen/adenosine 5'-diphosphate (CADP)-coated membranes (closure times, CTs) were measured. CEPI CADP CTs non-incubated blood 125.6 ± 19.5 s 93.0 ± 12.2 s, respectively, no significant difference observed incubation comparable each time. These findings suggest that has
elsevier.com
sci-hub.se 参考文章(27)
Peter J. Wormald, Graham van Renen, Jonathon Perks, Janine A. Jones, Claire D. Langton-Hewer, The effect of the total intravenous anesthesia compared with inhalational anesthesia on the surgical field during endoscopic sinus surgery American Journal of Rhinology. ,vol. 19, pp. 514- 520 ,(2005) , 10.1177/194589240501900516
Paul Harrison, Progress in the assessment of platelet function. British Journal of Haematology. ,vol. 111, pp. 733- 744 ,(2000) , 10.1046/J.1365-2141.2000.02269.X
Sourav Kundu, Eric Heilmann, Reynaldo Sio, Carmen Garcia, Rosa Davidson, Roy Ostgaard, Description of an in vitro platelet function analyzer--PFA-100. Seminars in Thrombosis and Hemostasis. ,vol. 21, pp. 106- 112 ,(1995) , 10.1055/S-0032-1313612
Hannah Wunsch, Jeremy M. Kahn, Andrew A. Kramer, Gordon D. Rubenfeld, Use of intravenous infusion sedation among mechanically ventilated patients in the United States. Critical Care Medicine. ,vol. 37, pp. 3031- 3039 ,(2009) , 10.1097/CCM.0B013E3181B02EFF
Karger, Heim, Beeser, Weber, Kretschmer, Böck, De Haan, Beck, Gutensohn, Hertfelder, Standardization of the PFA-100® platelet function test in 105 mmol/l buffered citrate : effect of gender, smoking, and oral contraceptives British Journal of Haematology. ,vol. 106, pp. 898- 904 ,(1999) , 10.1046/J.1365-2141.1999.01660.X
Hyung-Seok Yoo, Jin Hee Han, Sung Wook Park, Keon Sik Kim, Comparison of surgical condition in endoscopic sinus surgery using remifentanil combined with propofol, sevoflurane, or desflurane Korean Journal of Anesthesiology. ,vol. 59, pp. 377- 382 ,(2010) , 10.4097/KJAE.2010.59.6.377
Ansgar Moeller, Monika Weippert-Kretschmer, Helge Prinz, Volker Kretschmer, Influence of ABO blood groups on primary hemostasis Transfusion. ,vol. 41, pp. 56- 60 ,(2001) , 10.1046/J.1537-2995.2001.41010056.X
J P De La Cruz, M V Páez, J A Carmona, F Sánchez De La Cuesta, Antiplatelet effect of the anaesthetic drug propofol: influence of red blood cells and leucocytes British Journal of Pharmacology. ,vol. 128, pp. 1538- 1544 ,(1999) , 10.1038/SJ.BJP.0702927
Hideo Hirakata, Kumi Nakamura, Bencharatana Yokubol, Hiroshi Toda, Yoshio Hatano, Nobukata Urabe, Kenjiro Mori, Propofol has both enhancing and suppressing effects on human platelet aggregation in vitro. Anesthesiology. ,vol. 91, pp. 1361- 1361 ,(1999) , 10.1097/00000542-199911000-00028
Eberhard Mammen, Philip Comp, Robert Gosselin, Charles Greenberg, W. Hoots, Craig Kessler, Edward Larkin, Darla Liles, Diane Nugent, PFA-100 system: a new method for assessment of platelet dysfunction. Seminars in Thrombosis and Hemostasis. ,vol. 24, pp. 195- 202 ,(1998) , 10.1055/S-2007-995840