Proteomic profiling of the autoimmune response to breast cancer antigens uncovers a suppressive effect of hormone therapy.

摘要: Purpose Proteomics technologies are well suited for harnessing the immune response to tumor antigens diagnostic applications as in case of breast cancer. We previously reported a substantial impact hormone therapy (HT) on proteome. Here, we investigated effect HT toward antigens. Experimental design Plasmas collected 0–10 months prior diagnosis ER+ cancer from 190 postmenopausal women and controls that participated Women's Health Initiative Observational Study were analyzed IgG reactivity against arrayed proteins MCF-7 or SKBR3 cell line lysates following extensive fractionation. Results HT user cases exhibited significantly reduced autoantibody compared who Not Current users. An associated level IL-6 other immune-related cytokines was observed among users relative nonusers. Conclusion clinical relevance Our findings suggest occurrence global altered cancer-derived with HT. Thus full understanding factors modulate is necessary translate panels into applications.