The human immunodeficiency virus-reverse transcriptase inhibition activity of novel pyridine/pyridinium-type fullerene derivatives.
作者： Takumi Yasuno , Tomoyuki Ohe , Kyoko Takahashi , Shigeo Nakamura , Tadahiko Mashino
DOI: 10.1016/J.BMCL.2015.05.086
关键词: Fullerene derivatives 、 Chemistry 、 Human immunodeficiency virus (HIV) 、 Cytotoxicity 、 Pyridine 、 Pyridinium 、 Biochemistry 、 Reverse transcriptase
摘要: In the present study, we describe synthesis of a novel set pyridine/pyridinium-type fullerene derivatives. The products were assessed for human immunodeficiency virus-reverse transcriptase inhibition activities. All derivatives showed potent without cytotoxicity.
elsevier.com
sci-hub.se 参考文章(14)
N. Tsao, T.-Y. Luh, C.-K. Chou, T.-Y. Chang, J.-J. Wu, C.-C. Liu, H.-Y. Lei, In vitro action of carboxyfullerene Journal of Antimicrobial Chemotherapy. ,vol. 49, pp. 641- 649 ,(2002) , 10.1093/JAC/49.4.641
Susanna Bosi, Tatiana Da Ros, Giampiero Spalluto, Maurizio Prato, Fullerene derivatives: an attractive tool for biological applications European Journal of Medicinal Chemistry. ,vol. 38, pp. 913- 923 ,(2003) , 10.1016/J.EJMECH.2003.09.005
Tadahiko Mashino, Dai Nishikawa, Kyoko Takahashi, Noriko Usui, Takao Yamori, Masako Seki, Toyoshige Endo, Masataka Mochizuki, Antibacterial and antiproliferative activity of cationic fullerene derivatives. Bioorganic & Medicinal Chemistry Letters. ,vol. 13, pp. 4395- 4397 ,(2003) , 10.1016/J.BMCL.2003.09.040
H. W. Kroto, J. R. Heath, S. C. O’Brien, R. F. Curl, R. E. Smalley, C 60 : Buckminsterfullerene Nature. ,vol. 318, pp. 162- 163 ,(1985) , 10.1038/318162A0
Glenn A. Burley, Paul A. Keller, Stephen G. Pyne, [60]Fullerene Amino Acids and Related Derivatives Fullerene Science and Technology. ,vol. 7, pp. 973- 1001 ,(1999) , 10.1080/10641229909350301
Hidetoshi Tokuyama, Shigeru Yamago, Eiichi Nakamura, Takashi Shiraki, Yukio Sugiura, Photoinduced biochemical activity of fullerene carboxylic acid Journal of the American Chemical Society. ,vol. 115, pp. 7918- 7919 ,(1993) , 10.1021/JA00070A064
Simon H. Friedman, Padma S. Ganapathi, Yves Rubin, George L. Kenyon, Optimizing the binding of fullerene inhibitors of the HIV-1 protease through predicted increases in hydrophobic desolvation. Journal of Medicinal Chemistry. ,vol. 41, pp. 2424- 2429 ,(1998) , 10.1021/JM970689R
Susanna Bosi, Tatiana Da Ros, Sabrina Castellano, Elena Banfi, Maurizio Prato, Antimycobacterial activity of ionic fullerene derivatives Bioorganic & Medicinal Chemistry Letters. ,vol. 10, pp. 1043- 1045 ,(2000) , 10.1016/S0960-894X(00)00159-1
Michele Maggini, Gianfranco Scorrano, Maurizio Prato, Addition of azomethine ylides to C60: synthesis, characterization, and functionalization of fullerene pyrrolidines Journal of the American Chemical Society. ,vol. 115, pp. 9798- 9799 ,(1993) , 10.1021/JA00074A056
Darrin A. Barr, Michael J. Dorrity, Ronald Grigg, Simon Hargreaves, John F. Malone, John Montgomery, James Redpath, Paul Stevenson, Mark Thornton-Pett, X=Y−ZH compounds as potential 1,3-dipoles. Part 43. Metal ion catalysed asymmetric 1,3-dipolar cycloaddition reactions of imines and menthyl acrylate☆ Tetrahedron. ,vol. 51, pp. 273- 294 ,(1995) , 10.1016/0040-4020(94)00940-V