Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase.
作者： Alastair D. Grant , Michael Shapira , Hermona Soreq
关键词: Locus (genetics) 、 Reverse transcription polymerase chain reaction 、 Molecular biology 、 Acetylcholinesterase 、 Aché 、 Gene 、 Biology 、 Cholinergic neurotransmission 、 Predictive methods 、 Computational analysis
摘要: The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), a novel previously unidentified (PIX), co-oriented with ACHE. Experimental evidence shows coregulation murine ACHE ARS following confined swim, indicating coordinated response stress, that is possibly mediated by altered cholinergic neurotransmission.
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