Function and structure of the vascular wall in experimental arterial hypertension. Effect of treatment

摘要: The effects of converting enzyme inhibitor have been studied on the functions and structure arterial wall, in both models renovascular spontaneously hypertensive rats. wall terms active vasomotricity, passive elasticity transparietal convexion transport proteins. Whatever model used, hypertension was associated with significant changes functions: increase smooth muscle cell tone, decrease compliance, filtration rate These modifications could be reported to thickness media secondary hypertrophy hyperplasia collagen network density. inhibitors these phenomenons depend experimental used duration treatment. In animals, one month treatment perindopril normalized blood pressure compliance wall. This functional benefit easily complete regression observed after By contrast, density not regressed by trandolapril thus proteins remained decreased. rats a long (3 months) partially change compliance. effect, once again, partial medial which associated, this condition,