Proximal colorectal dysplasia or cancer in ulcerative colitis. The impact of primary sclerosing cholangitis and sulfasalazine: results from a 20-year surveillance study.

摘要: PURPOSE: Known risk factors for the development of colorectal dysplasia or cancer in ulcerative colitis are total colonic involvement and long duration disease. It has recently been suggested that presence primary sclerosing cholangitis is another independent factor—especially proximal cancer—and treatment with sulfasalazine might reduce frequency colitis; present study was undertaken to shed light on validity these theories. METHODS: A 143 patients underwent regular colonoscopies multiple biopsies a 20-year surveillance program studies long-standing colitis. Fifty-one developed cancer. Patient records were scrutinized retrospectively information cholangitis, site malignancy, results treatment. RESULTS: Nineteen had cholangitis; ran significantly higher developing than only. All cancers (n=3) 75 percent all dysplasias among located part colon, whereas 36 found same region without (P=0.02). Sulfasalazine showed no significant protective effect CONCLUSION: The evaluation, as assessed by multivariate analysis, shows proves be an additional factor colitis—particularly colon. findings do not support theory exerts against