Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate‐nitrite‐nitric oxide pathway

作者: Satnam Lidder , Andrew J. Webb

DOI: 10.1111/J.1365-2125.2012.04420.X

关键词: Endothelial dysfunctionFood scienceBiochemistryNitrateNutrientVitamin CNitric oxideIngestionMediterranean dietNitriteChemistry

摘要: … nitrate capsules, and demonstrated a dose dependent reduction in BP (with 4, 12 and 24 mmol nitrate) equivalent to beetroot juice [nitrate] … a BP lowering effect of nitrate rich vegetables …

参考文章(222)
Chun-You Wang, Yi-Hua Wu, Fang Liu, Yuan Tian, Dao-Da Chen, Zhong Yao, Ping Lü, Jing-Hui Zhang, Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia-reperfusion injury. Hepatobiliary & Pancreatic Diseases International. ,vol. 4, pp. 350- 355 ,(2005)
V P Reutov, E G Sorokina, NO-SYNTHASE AND NITRITE-REDUCTASE COMPONENTS OF NITRIC OXIDE CYCLE Biochemistry. ,vol. 63, pp. 874- 884 ,(1998)
Charalambos Vlachopoulos, Konstantinos Aznaouridis, Christodoulos Stefanadis, Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. Journal of the American College of Cardiology. ,vol. 55, pp. 1318- 1327 ,(2010) , 10.1016/J.JACC.2009.10.061
D.N. Maynard, A.V. Barker, P.L. Minotti, N.H. Peck, Nitrate Accumulation in Vegetables Advances in Agronomy. ,vol. 28, pp. 71- 118 ,(1976) , 10.1016/S0065-2113(08)60553-2
Jon O. Lundberg, Eddie Weitzberg, Mark T. Gladwin, The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics Nature Reviews Drug Discovery. ,vol. 7, pp. 156- 167 ,(2008) , 10.1038/NRD2466
William M. Deen, Steven R. Tannenbaum, Dale S. Schultz, Vernon R. Young, David A. Wagner, Metabolic Fate of an Oral Dose of 15N-labeled Nitrate in Humans: Effect of Diet Supplementation with Ascorbic Acid Cancer Research. ,vol. 43, pp. 1921- 1925 ,(1983)
Amy L. Sindler, Bradley S. Fleenor, John W. Calvert, Kurt D. Marshall, Melanie L. Zigler, David J. Lefer, Douglas R. Seals, Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging. Aging Cell. ,vol. 10, pp. 429- 437 ,(2011) , 10.1111/J.1474-9726.2011.00679.X
Mitsuru Futakuchi, Masao Hirose, Shoji Fukushima, Satoru Takahashi, Hikaru Tanaka, Nobuyuki Ito, Effects of Sodium Nitrite and Catechol, 3-Methoxycatechol, or Butylated Hydroxyanisole in Combination in a Rat Multiorgan Carcinogenesis Model Cancer Research. ,vol. 53, pp. 32- 37 ,(1993)
Yong Li, Jifeng Zhang, Francisco J Schopfer, Dariusz Martynowski, Minerva T Garcia-Barrio, Amanda Kovach, Kelly Suino-Powell, Paul R S Baker, Bruce A Freeman, Y Eugene Chen, H Eric Xu, Molecular recognition of nitrated fatty acids by PPAR gamma. Nature Structural & Molecular Biology. ,vol. 15, pp. 865- 867 ,(2008) , 10.1038/NSMB.1447
Arthur N. Donaldson, THE RELATION OF PROTEIN FOODS TO HYPERTENSION. California and western medicine. ,vol. 24, pp. 328- 331 ,(1926)