Genome-based vaccine design: the promise for malaria and other infectious diseases

摘要: Vaccines are one of the most effective interventions to improve public health, however, generation highly vaccines for many diseases has remained difficult. Three chronic that characterise these difficulties include malaria, tuberculosis and HIV, they alone account half global infectious disease burden. The whole organism vaccine approach pioneered by Jenner in 1796 refined Pasteur 1857 with "isolate, inactivate inject" paradigm proved successful viral bacterial pathogens causing acute but failed respect HIV as well other diseases. A significant advance past decade been elucidation genomes, proteomes transcriptomes pathogens. This information provides foundation new 21st Century approaches identify target antigens development vaccines, drugs diagnostic tests. Innovative genome-based strategies have shown potential a number challenging pathogens, including malaria. We advocate rational design will overcome problem poorly immunogenic, protective plagued developers years.