关键词: Hemoglobin 、 Decompression 、 Medicine 、 Surgery 、 Simulated altitude 、 Acclimatization 、 Hypoxia (medical) 、 pCO2 、 Anesthesia 、 Effects of high altitude on humans 、 Hypobaric chamber
摘要: Exposure to high altitude induces physiological or pathological modifications that are not always clearly attributable a specific environmental factor: hypoxia, cold, stress, inadequate food. The principal goal of hypobaric chamber studies is determine the effect hypoxia. Eight male volunteers (“altinauts”), aged 23 37 were selected. They first pre-acclimatized in Observatoire Vallot (4,350m) before entering chamber. was progressively decompressed down 253 mmHg barometric pressure, with recovery period 3 days at 5,000m middle decompression period. spent total 31 Eighteen protocols organized by 14 European teams, exploring limiting factors physical and psychological performance, pathophysiology acute mountain sickness (AMS). All subjects reached 8,000m 7 them simulated 8,848m. Three altinauts complained transient neurological symptoms which resolved rapidly reoxygenation. Body weight decreased 5.4 kg through negative caloric balance. Only four after return sea-level, had recovered 3.4 kg, i.e. 63% loss. At 8,848m (n=5), PaO2 30.6 ± 1.4 mmHg, PCO2 11.9 pH 7.58 0.02 (arterialized capillary blood). Hemoglobin concentration increased from 14.8±1.4 18.4±1.5 g/d1 within 4 sea-level. AMS score 6,000m maximal 7,000m, especially for sleep. related alteration color vision elevation body temperature. VO2MAX 59% 7,000m. purpose this paper give general description study time course main clinical parameters. “summit“ (for some three consecutive times) better conditions than it would have been possible mountains, probably because acclimatization other such as cold nutrition controlled.