Operation Everest III: COMEX '97.

作者: Jean-Paul Richalet

DOI: 10.1089/HAM.2009.1099

关键词: HemoglobinDecompressionMedicineSurgerySimulated altitudeAcclimatizationHypoxia (medical)pCO2AnesthesiaEffects of high altitude on humansHypobaric chamber

摘要: Exposure to high altitude induces physiological or pathological modifications that are not always clearly attributable a specific environmental factor: hypoxia, cold, stress, inadequate food. The principal goal of hypobaric chamber studies is determine the effect hypoxia. Eight male volunteers (“altinauts”), aged 23 37 were selected. They first pre-acclimatized in Observatoire Vallot (4,350m) before entering chamber. was progressively decompressed down 253 mmHg barometric pressure, with recovery period 3 days at 5,000m middle decompression period. spent total 31 Eighteen protocols organized by 14 European teams, exploring limiting factors physical and psychological performance, pathophysiology acute mountain sickness (AMS). All subjects reached 8,000m 7 them simulated 8,848m. Three altinauts complained transient neurological symptoms which resolved rapidly reoxygenation. Body weight decreased 5.4 kg through negative caloric balance. Only four after return sea-level, had recovered 3.4 kg, i.e. 63% loss. At 8,848m (n=5), PaO2 30.6 ± 1.4 mmHg, PCO2 11.9 pH 7.58 0.02 (arterialized capillary blood). Hemoglobin concentration increased from 14.8±1.4 18.4±1.5 g/d1 within 4 sea-level. AMS score 6,000m maximal 7,000m, especially for sleep. related alteration color vision elevation body temperature. VO2MAX 59% 7,000m. purpose this paper give general description study time course main clinical parameters. “summit“ (for some three consecutive times) better conditions than it would have been possible mountains, probably because acclimatization other such as cold nutrition controlled.

参考文章(41)
A. Cymerman, C. S. Houston, M. K. Malconian, P. Rock, J. R. Sutton, J. Devine, Operation Everest II: Altitude decompression sickness during repeated altitude exposure. Aviation, Space, and Environmental Medicine. ,vol. 58, pp. 679- 682 ,(1987)
Erick Dousset, Patrick Decherchi, Laurent Grelot, Yves Jammes, Comparison between the effects of chronic and acute hypoxaemia on muscle afferent activities from the tibialis anterior muscle Experimental Brain Research. ,vol. 148, pp. 320- 327 ,(2003) , 10.1007/S00221-002-1297-0
A. Cymerman, J. T. Reeves, J. R. Sutton, P. B. Rock, B. M. Groves, M. K. Malconian, P. M. Young, P. D. Wagner, C. S. Houston, Operation Everest II: maximal oxygen uptake at extreme altitude. Journal of Applied Physiology. ,vol. 66, pp. 2446- 2453 ,(1989) , 10.1152/JAPPL.1989.66.5.2446
K. R. Westerterp, B. Kayser, L. Wouters, J. L. Le Trong, J. P. Richalet, Energy balance at high altitude of 6,542 m Journal of Applied Physiology. ,vol. 77, pp. 862- 866 ,(1994) , 10.1152/JAPPL.1994.77.2.862
M. S. Rose, C. S. Houston, C. S. Fulco, G. Coates, J. R. Sutton, A. Cymerman, Operation Everest. II: Nutrition and body composition Journal of Applied Physiology. ,vol. 65, pp. 2545- 2551 ,(1988) , 10.1152/JAPPL.1988.65.6.2545
ALAIN BOUSSUGES, FLORENCE MOLENAT, HENRI BURNET, EMMANUEL CAUCHY, BERNARD GARDETTE, JEAN-MARIE SAINTY, YVES JAMMES, JEAN-PAUL RICHALET, Operation Everest III (Comex '97): modifications of cardiac function secondary to altitude-induced hypoxia. An echocardiographic and Doppler study. American Journal of Respiratory and Critical Care Medicine. ,vol. 161, pp. 264- 270 ,(2000) , 10.1164/AJRCCM.161.1.9902096
J. R. Sutton, J. T. Reeves, P. D. Wagner, B. M. Groves, A. Cymerman, M. K. Malconian, P. B. Rock, P. M. Young, S. D. Walter, C. S. Houston, Operation Everest II: oxygen transport during exercise at extreme simulated altitude Journal of Applied Physiology. ,vol. 64, pp. 1309- 1321 ,(1988) , 10.1152/JAPPL.1988.64.4.1309
J. M. Shen, C. Palsule, S. Gangopadhyay, H. A. Naseem, S. Kizzar, Freddy H. C. Goh, Characterization of fluorinated hydrogenated amorphous silicon nitride (a‐SiNx:H) alloys Journal of Applied Physics. ,vol. 76, pp. 1055- 1061 ,(1994) , 10.1063/1.357823
J. H. Abraini, C. Bouquet, F. Joulia, M. Nicolas, B. Kriem, Cognitive performance during a simulated climb of Mount Everest: implications for brain function and central adaptive processes under chronic hypoxic stress Pflügers Archiv: European Journal of Physiology. ,vol. 436, pp. 553- 559 ,(1998) , 10.1007/S004240050671