Mesolimbic dopamine activation--the key to nicotine reinforcement?

摘要: The mesolimbic dopaminergic system appears to mediate the rewarding effects of certain stimulant drugs, such as (+)amphetamine. Autoradiographic mapping techniques have revealed that these neurons are potential targets for nicotine, since they possess nicotinic receptors located on their cell bodies and terminals in rat brain. Functional studies consistent with this proposal: nicotine can increase firing rate neurons, nicotine-induced dopamine release has been demonstrated vitro vivo. locomotor effect resulting from acute administration is accompanied by, be dependent upon, activation neurons. Likewise, destruction attenuate intravenous rats. Thus, when administered intermittently, like other may activate system, action contribute tobacco habit.