Direct laser writing of 3D scaffolds for neural tissue engineering applications.
作者： V Melissinaki , A A Gill , I Ortega , M Vamvakaki , A Ranella
DOI: 10.1088/1758-5082/3/4/045005
关键词: Prepolymer 、 Thin film 、 Polymerization 、 Methacrylate 、 Neural tissue engineering 、 Laser 、 Nanotechnology 、 Femtosecond 、 Materials science 、 Biocompatibility
摘要: This study reports on the production of high-resolution 3D structures polylactide-based materials via multi-photon polymerization and explores their use as neural tissue engineering scaffolds. To achieve this, a liquid polylactide resin was synthesized in house rendered photocurable attaching methacrylate groups to hydroxyl end small molecular weight prepolymer. cures easily under UV irradiation, using mercury lamp, femtosecond IR irradiation. The results showed that (PLA) can be readily structured direct laser write (DLW) with Ti:sapphire submicrometer produced. maximum resolution achieved is 800 nm. Neuroblastoma cells were grown thin films cured PLA material, cell viability proliferation assays revealed good biocompatibility material. Additionally, PC12 NG108-15 neuroblastoma growth bespoke scaffolds studied more detail assess potential applications for neuronal implants this
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