Glucose Sensing Using Near-Infrared Surface-Enhanced Raman Spectroscopy: Gold Surfaces, 10-Day Stability, and Improved Accuracy

摘要: This research presents the achievement of significant milestones toward development a minimally invasive, continuously monitoring, glucose-sensing platform based on optical quantitation glucose in interstitial fluid. We expand our initial successes measurement by surface-enhanced Raman scattering (SERS), demonstrating substantial improvements not only quality and properties substrate system itself but also robustness methodology amenability technique to compact, diode laser-based instrumentation. Herein, we compare long-term stability gold silver film over nanosphere (AuFON, AgFON) substrates functionalized with partitioning self-assembled monolayer (SAM) using both electrochemical SERS measurements. AuFONs were found be stable for period at least 11 days. The switch provides more surface SAM formation yields better chemometric results, improv...