A General and Efficient Catalyst for Palladium-Catalyzed C―O Coupling Reactions of Aryl Halides with Primary Alcohols
作者： Saravanan Gowrisankar , Alexey G. Sergeev , Pazhamalai Anbarasan , Anke Spannenberg , Helfried Neumann
DOI: 10.1021/JA103248D
关键词: Yield (chemistry) 、 Palladium 、 Organic chemistry 、 Regioselectivity 、 Alkyl 、 Chemistry 、 Aryl 、 Ligand 、 Catalysis 、 Coupling reaction
摘要: An efficient procedure for palladium-catalyzed coupling reactions of (hetero)aryl bromides and chlorides with primary aliphatic alcohols has been developed. Key to the success is synthesis exploitation novel bulky di-1-adamantyl-substituted bipyrazolylphosphine ligand L6. Reaction aryl halides including activated, nonactivated, as well gave corresponding alkyl ethers in high yield. Noteworthy, functionalizations presence secondary tertiary proceed excellent regioselectivity.
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