Naturally occurring benzofuran: isolation, structure elucidation and total synthesis of 5-(3-hydroxypropyl)-7-methoxy-2-(3′-methoxy-4′-hydroxyphenyl)-3-benzo[b]furancarbaldehyde, a novel adenosine A1 receptor ligand isolated from salvia miltiorrhiza bunge (danshen)
作者： Zhen Yang , Po Ming Hon , Kuk Ying Chui , Zun Le Xu , Hson Mou Chang
DOI: 10.1016/S0040-4039(00)78908-8
关键词: Chemistry 、 Phenols 、 Salvia miltiorrhiza 、 Total synthesis 、 Ligand (biochemistry) 、 Biological activity 、 Benzofuran 、 Bicyclic molecule 、 Stereochemistry 、 Adenosine A1 receptor
摘要: Abstract A naturally occurring benzofuran, namely 5-(3-hydroxypropyl)-7-methoxy-2-(3′-methoxy-4′-hydroxyphenyl)-3-benzo[ b ]furancarbaldehyde was isolated from the roots of S. miltiorrhiza Bunge “Danshen”. Its structure established by means spectroscopic methods as well a total synthesis. Both natural and synthetic compounds showed high potency (IC 50 = 17 nM 10 nM, respectively) in bovine adenosine 1 radioligand binding. The title compound root (Danshen) its
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