Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation.
作者： Alberto Mantovani , Antonio Sica , Paola Allavena , Cecilia Garlanda , Massimo Locati
DOI: 10.1016/J.HUMIMM.2009.02.008
关键词: Suppressor 、 Metastasis 、 Macrophage 、 Cell biology 、 Cancer 、 Biology 、 Macrophage inflammatory protein 、 Inflammation 、 Myeloid-derived Suppressor Cell 、 Tumor progression
摘要: Macrophages undergo a wide spectrum of polarized activation states, and have the potential both to elicit tumor tissue destructive reactions promote progression (macrophage balance). In general, tumor-associated macrophages (TAM) from established tumors related myeloid-derived suppressor cells are diverse properties M2-activated cells. As such, they help cancer metastasis. Therefore, TAM key component pathways connecting inflammation cancer.
elsevier.com
sci-hub.se 参考文章(86)
Elaine Y. Lin, Valerie Gouon-Evans, Andrew V. Nguyen, Jeffrey W. Pollard, The macrophage growth factor CSF-1 in mammary gland development and tumor progression. Journal of Mammary Gland Biology and Neoplasia. ,vol. 7, pp. 147- 162 ,(2002) , 10.1023/A:1020399802795
M. Browatzki, R. Kranzhöfer, C. A. H. Pfeiffer, J. Schmidt, Endothelin-1 induces CD40 but not IL-6 in human monocytes via the proinflammatory transcription factor NF-kappaB. European Journal of Medical Research. ,vol. 10, pp. 197- 201 ,(2005)
Naofumi Nagasue, Hiroyuki Inagawa, Gen-Ichiro Soma, Shuhei Ueda, Mitsuo Tachibana, Dipok Kumar Dhar, Masaki Inoue, Satoshi Ohno, Toshiyuki Fujii, Nobutaka Suzuki, The degree of macrophage infiltration into the cancer cell nest is a significant predictor of survival in gastric cancer patients. Anticancer Research. ,vol. 23, pp. 5015- 5022 ,(2003)
Jeffrey W. Pollard, Tumour-educated macrophages promote tumour progression and metastasis Nature Reviews Cancer. ,vol. 4, pp. 71- 78 ,(2004) , 10.1038/NRC1256
Lothar Hennighausen, John S. Condeelis, Jeffrey E. Segall, Jeffrey W. Pollard, Elaine Y. Lin, Weigang Wang, Yarong Wang, Jun ichi Miyazaki, Fayyaz Ahmed, Jeffrey Wyckoff, Joan Jones, GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice. Cancer Research. ,vol. 62, pp. 7166- 7169 ,(2002)
Russell D. Leek, Adrian L. Harris, Tumor-associated macrophages in breast cancer. Journal of Mammary Gland Biology and Neoplasia. ,vol. 7, pp. 177- 189 ,(2002) , 10.1023/A:1020304003704
Ivan Shabo, Olle Stål, Hans Olsson, Siv Doré, Joar Svanvik, Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival. International Journal of Cancer. ,vol. 123, pp. 780- 786 ,(2008) , 10.1002/IJC.23527
Sergei Kusmartsev, Dmitry I. Gabrilovich, STAT1 Signaling Regulates Tumor-Associated Macrophage-Mediated T Cell Deletion The Journal of Immunology. ,vol. 174, pp. 4880- 4891 ,(2005) , 10.4049/JIMMUNOL.174.8.4880
Sergei Kusmartsev, Yulia Nefedova, Daniel Yoder, Dmitry I. Gabrilovich, Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. Journal of Immunology. ,vol. 172, pp. 989- 999 ,(2004) , 10.4049/JIMMUNOL.172.2.989
Robert J. Moore, David M. Owens, Gordon Stamp, Caroline Arnott, Frances Burke, Nick East, Hazel Holdsworth, Lynn Turner, Barrett Rollins, Manolis Pasparakis, George Kollias, Frances Balkwill, Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nature Medicine. ,vol. 5, pp. 828- 831 ,(1999) , 10.1038/10552