A quantitative analysis of the acidosis of cardiac arrest: a prospective observational study.

作者: Jun Makino , Shigehiko Uchino , Hiroshi Morimatsu , Rinaldo Bellomo

DOI: 10.1186/CC3714

关键词: Intensive care medicineCalcium metabolismAnesthesiaMedicineComorbidityMetabolic acidosisAdvanced life supportAcidosisEmergency departmentHyperlactatemiaProspective cohort study

摘要: Introduction Metabolic acidosis is common in patients with cardiac arrest and conventionally considered to be essentially due hyperlactatemia. However, hyperlactatemia alone fails explain the cause of metabolic acidosis. Recently, Stewart– Figge methodology has been found useful explaining quantifying acid–base changes various clinical situations. This novel quantitative might also provide insight into factors responsible for arrest. We proposed that not sole other participate significantly its development. Methods One hundred five out-of-hospital 28 minor injuries (comparison group) who were admitted Emergency Department a tertiary hospital Tokyo prospectively included this study. Serum sodium, potassium, ionized calcium, magnesium, chloride, lactate, albumin, phosphate blood gases measured as soon feasible upon arrival emergency department later analyzed using Stewart–Figge methodology.

参考文章(31)
David J. Durand, Interpretation of Blood Gases Manual of Neonatal Respiratory Care. pp. 159- 166 ,(2012) , 10.1007/978-1-4614-2155-9_19
James A. Tuchschmidt, Carter E. Mecher, Predictors of Outcome From Critical Illness. Shock and Cardiopulmonary Resuscitation Critical Care Clinics. ,vol. 10, pp. 179- 195 ,(1994) , 10.1016/S0749-0704(18)30155-6
T Mydosh, J Figge, V Fencl, Serum proteins and acid-base equilibria: a follow-up. Journal of Laboratory and Clinical Medicine. ,vol. 120, pp. 713- 719 ,(1992)
M Lazzeri, S Lupetti, C Cristofano, M Cerri, S Giovannetti, G Barsotti, The role of metabolic acidosis in causing uremic hyperphosphatemia Mineral and Electrolyte Metabolism. ,vol. 12, pp. 103- 106 ,(1986)
T. H. Rossing, N. Maffeo, V. Fencl, Acid-base effects of altering plasma protein concentration in human blood in vitro Journal of Applied Physiology. ,vol. 61, pp. 2260- 2265 ,(1986) , 10.1152/JAPPL.1986.61.6.2260
D. A. Story, S. Poustie, R. Bellomo, Quantitative physical chemistry analysis of acid-base disorders in critically ill patients. Anaesthesia. ,vol. 56, pp. 530- 533 ,(2001) , 10.1046/J.1365-2044.2001.01983.X
W.F. Dick, Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Notfall & Rettungsmedizin. ,vol. 3, pp. 331- 332 ,(2000) , 10.1007/S100490070024
Brian M. Gilfix, Mark Bique, Sheldon Magder, A physical chemical approach to the analysis of acid-base balance in the clinical setting Journal of Critical Care. ,vol. 8, pp. 187- 197 ,(1993) , 10.1016/0883-9441(93)90001-2