Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase.
作者： Yiying Huang , Cuiyan Tan , Jian Wu , Meizhu Chen , Zhenguo Wang
DOI: 10.1186/S12931-020-01429-6
关键词: Pulmonary function testing 、 Diffusing capacity 、 Gastroenterology 、 Respiratory muscle 、 FEV1/FVC ratio 、 Spirometry 、 Lung volumes 、 Medicine 、 Convalescence 、 Internal medicine 、 DLCO
摘要: This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase. A retrospective COVID-19 patients at Fifth Affiliated Hospital Sun Yat-sen University were conducted, with serial assessments including volumes (TLC), spirometry (FVC, FEV1), diffusing capacity for carbon monoxide (DLCO),respiratory muscle strength, 6-min walking distance (6MWD) and high resolution CT being collected 30 days after discharged. Fifty-seven completed assessments. There 40 non-severe cases 17 severe cases. Thirty-one (54.3%) had abnormal findings. Abnormalities detected pulmonary tests 43 (75.4%) patients. Six (10.5%), 5(8.7%), 25(43.8%) 7(12.3%), 30 (52.6%) FVC, FEV1, FEV1/FVC ratio, TLC, DLCO values less than 80% predicted values, respectively. 28 (49.1%) 13 (22.8%) PImax PEmax corresponding values. Compared cases, showed higher incidence impairment (75.6%vs42.5%, p = 0.019), total severity score (TSS) R20, significantly lower percentage TLC 6MWD. No significant correlation between TSS parameters was found during follow-up visit. Impaired diffusing-capacity, respiratory imaging abnormalities more half a encountered decrease 6MWD decline.
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