Identification of Licopyranocoumarin and Glycyrurol from Herbal Medicines as Neuroprotective Compounds for Parkinson's Disease
作者： Takahiro Fujimaki , Shinji Saiki , Etsu Tashiro , Daisuke Yamada , Mitsuhiro Kitagawa
DOI: 10.1371/JOURNAL.PONE.0100395
关键词: Neuroprotection 、 Programmed cell death 、 Glycyrrhiza 、 Biology 、 Toxicity 、 Reactive oxygen species 、 Mitochondrion 、 Membrane potential 、 Apoptosis 、 Pharmacology 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: In the course of screening for anti-Parkinsonian drugs from a library traditional herbal medicines, we found that extracts choi-joki-to and daio-kanzo-to protected cells MPP+-induced cell death. Because commonly contain genus Glycyrrhiza, isolated licopyranocoumarin (LPC) glycyrurol (GCR) as potent neuroprotective principals Glycyrrhiza. LPC GCR markedly blocked neuronal PC12D death disappearance mitochondrial membrane potential, which were mediated by JNK. inhibited JNK activation through suppression reactive oxygen species (ROS) generation, thereby inhibiting These results indicated derived would be promising drug leads PD treatment in future.
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core.ac.uk 参考文章(68)
Manyam Bv, Sánchez-Ramos, Traditional and complementary therapies in Parkinson's disease. Advances in Neurology. ,vol. 80, pp. 565- 574 ,(1999)
Patricia A. Trimmer, M. Kathleen Borland, Paula M. Keeney, James P. Bennett, W. Davis Parker, Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies Journal of Neurochemistry. ,vol. 88, pp. 800- 812 ,(2004) , 10.1046/J.1471-4159.2003.02168.X
Ranjita Betarbet, Todd B. Sherer, Gillian MacKenzie, Monica Garcia-Osuna, Alexander V. Panov, J. Timothy Greenamyre, Chronic systemic pesticide exposure reproduces features of Parkinson's disease Nature Neuroscience. ,vol. 3, pp. 1301- 1306 ,(2000) , 10.1038/81834
Xin Lin, Yu-Jun Wang, Qing Li, Yuan-Yuan Hou, Min-Hua Hong, Ying-Lin Cao, Zhi-Qiang Chi, Jing-Gen Liu, Chronic high‐dose morphine treatment promotes SH‐SY5Y cell apoptosis via c‐Jun N‐terminal kinase‐mediated activation of mitochondria‐dependent pathway FEBS Journal. ,vol. 276, pp. 2022- 2036 ,(2009) , 10.1111/J.1742-4658.2009.06938.X
Michael S. Saporito, Susan Carswell, Matthew S. Miller, Ellen M. Brown, CEP-1347/KT-7515, an Inhibitor of c-jun N-Terminal Kinase Activation, Attenuates the 1-Methyl-4-Phenyl Tetrahydropyridine-Mediated Loss of Nigrostriatal Dopaminergic Neurons In Vivo Journal of Pharmacology and Experimental Therapeutics. ,vol. 288, pp. 421- 427 ,(1999)
T.B. Ng, F. Liu, Z.T. Wang, Antioxidative activity of natural products from plants. Life Sciences. ,vol. 66, pp. 709- 723 ,(2000) , 10.1016/S0024-3205(99)00642-6
W. Davis Parker, Russell H. Swerdlow, MITOCHONDRIAL DYSFUNCTION IN IDIOPATHIC PARKINSON DISEASE American Journal of Human Genetics. ,vol. 62, pp. 758- 762 ,(1998) , 10.1086/301812
Shigenori Kumazawa, Masa Taniguchi, Yasuyuki Suzuki, Masayo Shimura, Mi-Sun Kwon, Tsutomu Nakayama, Antioxidant activity of polyphenols in carob pods Journal of Agricultural and Food Chemistry. ,vol. 50, pp. 373- 377 ,(2002) , 10.1021/JF010938R
Belén FERNÁNDEZ-PUNTERO, Irene BARROSO, Irene IGLESIAS, Juana BENEDÍ, Angel VILLAR, Antioxidant activity of Fraxetin: in vivo and ex vivo parameters in normal situation versus induced stress. Biological & Pharmaceutical Bulletin. ,vol. 24, pp. 777- 784 ,(2001) , 10.1248/BPB.24.777
Tiffini Voss, Bernard Ravina, Neuroprotection in Parkinson's disease: myth or reality? Current Neurology and Neuroscience Reports. ,vol. 8, pp. 304- 309 ,(2008) , 10.1007/S11910-008-0047-5