The effect of impurities on the toxicokinetics of malathion in rats
作者： D.L. Ryan , T.R. Fukuto
DOI: 10.1016/0048-3575(85)90103-8
关键词: Oral administration 、 Toxicokinetics 、 Chemistry 、 Acute toxicity 、 Corn oil 、 Urine 、 Malathion 、 Isomalathion 、 Metabolism 、 Biochemistry 、 Chromatography 、 Agronomy and Crop Science 、 Health, Toxicology and Mutagenesis 、 General Medicine
摘要: Abstract The effect of the malathion impurities, isomalathion O,S,S-trimethyl phosphorodithioate (OSS-Me), on toxicokinetic behavior [methoxy-14C]malathion in female rats was investigated. Malathion α- and β-monoacids diacid were predominant metabolites blood pretreated orally with corn oil followed 4 hr later radiolabeled malathion. Pretreatment or OSS-Me by treatment resulted a decrease total radioactive blood. Moreover, substantial reduction level β-monoacid observed impurity animals. These results indicate that impurities have stronger inhibiting carboxylesterases which preferentially hydrolyze β-carboethoxy moiety major excreted urine control generally matched those present potentiation acute toxicity pretreatment may be explained rat's capacity to degrade via carboxylesterase-catalyzed hydrolysis moiety.
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