Neurodevelopmental Genomics of Autism, Schizophrenia, and Related Disorders
作者： J.F. Cubells , D. Moreno-De-Luca
DOI: 10.1016/B978-0-12-397267-5.00027-3
关键词: Increasing risk 、 Schizophrenia (object-oriented programming) 、 Behavioral syndrome 、 Clinical psychology 、 Genomics 、 Autism 、 Psychology
摘要: Autism and schizophrenia are diagnostic terms referring to behavioral syndromes reflecting poorly understood heterogeneous neuro-developmental etiologies. A fundamental thesis of the current chapter is that both diagnoses most usefully conceived as spectra rather than unitary entities. Although modern classification systems consider autism-spectrum disorders (ASD) schizophrenia-spectrum (SSD) differ categorically, reviews historical commonalities in constructs ASD SSD, well recent evidence indicating specific genomic variants increase risk for ASD, SSD several other long considered be separate The particularly highlights copy-number (CNVs) a newly appreciated class variant associating with discusses CNV increasing sets disorders. concludes reformulation how research on CNV-related might conducted, implications design future genetic-epidemiological studies
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