Hyperparathyroidism is associated with reduced expression of a parathyroid calcium receptor mechanism defined by monoclonal antiparathyroid antibodies.

摘要: Parathyroid tissue from patients with hyperparathyroidism (HPT) exhibited reduced immunohistochemical reactivity monoclonal antiparathyroid antibodies, previously shown to stain intensely the surface of normal human parathyroid cells and interfere a receptor mechanism these which is involved in sensing gating Ca2+. hormone (PTH) release cytoplasmic Ca2+ concentrations (Cai2+) dispersed pathological glands had right-shifted dependencies on extracellular1 Ca2+, exposure antibodies rendered both Cai2+ PTH almost completely insensitive changes ambient The results suggest that expression calcium may be an important cause for aberrant HPT.