Local CRH Signaling Promotes Synaptogenesis and Circuit Integration of Adult-Born Neurons

摘要: Neural activity either enhances or impairs de novo synaptogenesis and circuit integration of neurons, but how this is mechanistically relayed in the adult brain largely unknown. Neuropeptide-expressing interneurons are widespread throughout key candidates for conveying neural downstream via neuromodulatory pathways that distinct from classical neurotransmission. With goal identifying signaling mechanisms underlie neuronal brain, we have virally traced local corticotropin-releasing hormone (CRH)-expressing inhibitory with extensive presynaptic inputs onto new neurons continuously integrated into rodent olfactory bulb. Local CRH adult-born promotes and/or stabilizes chemical synapses bulb, revealing a mechanism continued plasticity, synapse formation, brain.