Beyond mass spectrometry, the next step in proteomics
作者： Winston Timp , Gregory Timp
关键词: Genomics 、 Computational biology 、 Mass spectrometry 、 Proteomics 、 DNA sequencing 、 Peptide mapping 、 A protein 、 Computer science
摘要: Proteins can be the root cause of a disease, and they can be used to cure it. The need to identify these critical actors was recognized early (1951) by Sanger; the first biopolymer sequenced was a peptide, insulin. With the advent of scalable, single-molecule DNA sequencing, genomics and transcriptomics have since propelled medicine through improved sensitivity and lower costs, but proteomics has lagged behind. Currently, proteomics relies mainly on mass spectrometry (MS), but instead of truly sequencing, it …
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