Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan

作者: P. G. Scott , P. A. McEwan , C. M. Dodd , E. M. Bergmann , P. N. Bishop

DOI: 10.1073/PNAS.0402976101

关键词: Amino acidPeptide sequenceDecorinCrystallographyProteoglycanPolyproline helixCell surface receptorBiophysicsBiologyExtracellular matrixProtein structure

摘要: … small leucine-rich repeat proteoglycans and proteins (SLRPs), characterized by a protein core composed of leucine-rich … We report here the crystal structure of the dimeric protein core of …

参考文章(36)
Xiaolin L. He, J.Fernando Bazan, Gerry McDermott, Jong Bae Park, Kevin Wang, Marc Tessier-Lavigne, Zhigang He, K.Christopher Garcia, Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron. ,vol. 38, pp. 177- 185 ,(2003) , 10.1016/S0896-6273(03)00232-0
J Liu, T M Laue, H U Choi, L H Tang, L Rosenberg, The self-association of biglycan from bovine articular cartilage. Journal of Biological Chemistry. ,vol. 269, pp. 28366- 28373 ,(1994) , 10.1016/S0021-9258(18)46937-2
T. Krusius, E. Ruoslahti, Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 7683- 7687 ,(1986) , 10.1073/PNAS.83.20.7683
Renato V. Iozzo, David K. Moscatello, David J. McQuillan, Inge Eichstetter, Decorin Is a Biological Ligand for the Epidermal Growth Factor Receptor Journal of Biological Chemistry. ,vol. 274, pp. 4489- 4492 ,(1999) , 10.1074/JBC.274.8.4489
Bostjan Kobe, Andrey V Kajava, The leucine-rich repeat as a protein recognition motif Current Opinion in Structural Biology. ,vol. 11, pp. 725- 732 ,(2001) , 10.1016/S0959-440X(01)00266-4
Sarah Uff, Jeannine M. Clemetson, Tim Harrison, Kenneth J. Clemetson, Jonas Emsley, Crystal Structure of the Platelet Glycoprotein Ibα N-terminal Domain Reveals an Unmasking Mechanism for Receptor Activation Journal of Biological Chemistry. ,vol. 277, pp. 35657- 35663 ,(2002) , 10.1074/JBC.M205271200