The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer

摘要: The transcriptional repressor Capicua (CIC) has emerged as an important rheostat of cell growth regulated by RAS/MAPK signaling. Cic was originally discovered in Drosophila, where it shown to be inactivated MAPK signaling downstream the RTKs Torso and EGFR, which results signal-dependent responses that are required for normal fate specification, proliferation survival developing adult tissues. CIC is highly conserved mammals, also negatively Here, we review roles during mammalian development, tissue homeostasis, tumor formation therapy resistance. Available data indicate involved multiple biological processes, including lung liver autoimmunity neurobehavioral processes. Moreover, been development a suppressor, both human well mouse models. Finally, several lines evidence implicate determinant sensitivity EGFR pathway inhibitors, suggesting may play broader role cancer than anticipated.