Chromogranin A, a member of neuroendocrine secretory proteins as a selective marker for laboratory diagnosis of pheochromocytoma

摘要: The function of chromogranin A (CGA) is reviewed, and the radioimmunometric determination plasma CGA was evaluated as a marker pheochromocytoma using comparison patients immediately before surgery (group P, n=25, 635+/-451 ng/ml) with other groups patients, i.e. approximately 1 year after removal tumor PP, n=13, 69+/-33 ng/ml), medullary thyroid carcinoma M, n= 22, 106+/-59 congenital adrenal hyperplasy (n=33, 65+/-40 controls (n=31, 66+/-29 ng/ml). level above cut off value 130 ng/ml found in 24 25 group (relapse) 13 4 22 M. In P we significant association between size tumors removed concentrations (p=0.0016), also (p=0.0016) relationship PASS score rating malignity pheochromocytoma. We can conclude that concentration determined by assay (which simple without necessity special laboratory equipment) an effective to mass.