Free-Radical-Induced Oxidative and Reductive Degradation of Sulfa Drugs in Water: Absolute Kinetics and Efficiencies of Hydroxyl Radical and Hydrated Electron Reactions

作者： Stephen P. Mezyk , Thomas J. Neubauer , William J. Cooper , Julie R. Peller

关键词: Chemistry 、 Degradation (geology) 、 Ultrafast laser spectroscopy 、 Sulfanilic acid 、 Photochemistry 、 Hydroxyl radical 、 Solvated electron 、 Kinetics 、 Oxidative phosphorylation 、 Reaction rate constant

摘要: Absolute rate constants and degradation efficiencies for hydroxyl radical and hydrated electron reactions with four different sulfa drugs in water have been evaluated using a combination of electron pulse radiolysis/absorption spectroscopy and steady-state radiolysis/high-performance liquid chromatography measurements. For sulfamethazine, sulfamethizole, sulfamethoxazole, and sulfamerazine, absolute rate constants for hydroxyl radical oxidation were determined as (8.3±0.8)× 109,(7.9±0.4)× 109,(8.5±0.3)× 109, and …