Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level.

摘要: BACKGROUND: During stress, vasopressin is a potent synergistic factor of CRH as hypothalamic stimulator the HPA axis. The measurements and levels are cumbersome because their instability short half-life. Copeptin more stable peptide stoichiometrically released from same precursor molecule. aim our study was to compare copeptin cortisol in different stress situations. METHODS: Three groups patients with increasing were investigated: a) healthy controls without apparent (n=20), b) hospitalized medical moderate (n=25) c) surgical 30 minutes after extubation, maximal (n=29). In all we assessed levels. measured new sandwich immunoassay. RESULTS: Cortisol (median, IQ range, 486 [397-588] nmol/L), not significantly compared (438 [371-612] nmol/L, p=0.69). extubation higher (744 [645-1062] nmol/L p>0.01 vs patients). 4.3 [3.2-5.5] pmol/L, which lower (17.5 [6.4-24.1], p>0.001) (67.5 [37.8-110.0] p>0.001). correlation between r=0.46, p>0.001. CONCLUSION: novel marker individual level. It subtly mirrors values.