Gene-Nutrient Interactions in One-Carbon Metabolism

摘要: Advances in molecular biology greatly contributed, the past decades, to a deeper understanding of role gene function disease development. Environmental as well nutritional factors are now acknowledged interact with individual genetic background for development several diseases, including cancer, cardiovascular disease, and neurodegenerative diseases. The precise mechanisms such gene-nutrient interactions, however, not fully elucidated yet. Many micronutrients vitamins crucial regulating DNA metabolism. Indeed, folate has been most extensively investigated its unique mediator transfer one-carbon moieties nucleotide synthesis/repair biological methylation. Cell culture, animal, human studies, clearly demonstrated that deficiency induces disruption pathways methylation anomalies. Remarkably, interaction between status polymorphism methylenetetrahydrofolate reductase reported modulate genomic This observation suggests mutant genotype may expression through methylation, especially when affects key enzyme metabolism limits methyl supply. both genome-wide gene-specific, is particular interest study aging, other pathologic conditions, because it without permanent alterations sequence mutations or allele deletions. Understanding patterns nutrients critical issue, only provide pathophysiological explanations state, but also identify individuals at-risk conduct targeted diet-based interventions.