Increased percentages of T cells producing interleukin‐21 in patients with immune thrombocytopenic purpura
作者： Qian Zhang , Hai Bai , Wenhui Wang
DOI: 10.1002/CBIN.10220
关键词: Cytokine 、 Interleukin 21 、 T helper cell 、 Interleukin 、 Autoimmune Process 、 Medicine 、 Endocrinology 、 Internal medicine 、 Thrombocytopenic purpura 、 T cell 、 Immunology 、 Immune system
摘要: Interleukin (IL)-21, a cytokine which promotes differentiation of Th17, follicular helper T cell and B cells, may play an important role in controlling the autoimmune process immune thrombocytopenic purpura (ITP), acquired organ-specific hemorrhagic disease. The frequencies IL-21-producing cells serum levels IL-21 were determined by flow cytometry analysis ELISA, respectively, 24 ITP patients nine healthy controls. RT-PCR showed that circulating significantly higher than Serum expression with decreased after therapy, suggesting might be ITP.
sci-hub.se 参考文章(32)
Seda Oztürkmen, Lale Olcay, Betül Tavil, Mesude Falay, Zafer Biçakci, Arzu Akyay, Gülsüm Ozet, Hematogones in immune thrombocytopenic purpura: diagnostic implication. Turkish Journal of Pediatrics. ,vol. 53, pp. 219- ,(2011)
Hai Huang, Dhavalkumar D Patel, Kenneth G Manton, The immune system in aging: roles of cytokines, T cells and NK cells. Frontiers in Bioscience. ,vol. 10, pp. 192- 215 ,(2005) , 10.2741/1521
W.-H. Piao, Y. H. Jee, R. L. Liu, S. W. Coons, M. Kala, M. Collins, D. A. Young, D. I. Campagnolo, T. L. Vollmer, X.-F. Bai, A. La Cava, F.-D. Shi, IL-21 modulates CD4+ CD25+ regulatory T-cell homeostasis in experimental autoimmune encephalomyelitis. Scandinavian Journal of Immunology. ,vol. 67, pp. 37- 46 ,(2007) , 10.1111/J.1365-3083.2007.02035.X
C.-Q. JIN, F. LIU, H.-X. DONG, J. ZHANG, J.-W. ZHOU, L. SONG, H. XIAO, B.-Y. ZHENG, Type 2 polarized immune response holds a major position in Epstein–Barr virus‐related idiopathic thrombocytopenic purpura (EBV‐ITP) International Journal of Laboratory Hematology. ,vol. 34, pp. 164- 171 ,(2012) , 10.1111/J.1751-553X.2011.01375.X
Daisuke Kashiwakuma, Akira Suto, Yukiko Hiramatsu, Kei Ikeda, Hiroaki Takatori, Kotaro Suzuki, Shin-ichiro Kagami, Koichi Hirose, Norihiko Watanabe, Itsuo Iwamoto, Hiroshi Nakajima, B and T Lymphocyte Attenuator Suppresses IL-21 Production from Follicular Th Cells and Subsequent Humoral Immune Responses Journal of Immunology. ,vol. 185, pp. 2730- 2736 ,(2010) , 10.4049/JIMMUNOL.0903839
Yorihisa Kotobuki, Atsushi Tanemura, Lingli Yang, Saori Itoi, Mari Wataya-Kaneda, Hiroyuki Murota, Minoru Fujimoto, Satoshi Serada, Tetsuji Naka, Ichiro Katayama, Dysregulation of melanocyte function by Th17‐related cytokines: significance of Th17 cell infiltration in autoimmune vitiligo vulgaris Pigment Cell & Melanoma Research. ,vol. 25, pp. 219- 230 ,(2012) , 10.1111/J.1755-148X.2011.00945.X
Abderrahim Najaoui, Tamam Bakchoul, Johanna Stoy, Gregor Bein, Mathias J. Rummel, Sentot Santoso, Ulrich J. Sachs, Autoantibody‐mediated complement activation on platelets is a common finding in patients with immune thrombocytopenic purpura (ITP) European Journal of Haematology. ,vol. 88, pp. 167- 174 ,(2012) , 10.1111/J.1600-0609.2011.01718.X
Osamu Imataki, Sascha Ansén, Makito Tanaka, Marcus O. Butler, Alla Berezovskaya, Matthew I. Milstein, Kiyotaka Kuzushima, Lee M. Nadler, Naoto Hirano, IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8+ T cells Journal of Immunology. ,vol. 188, pp. 1609- 1619 ,(2012) , 10.4049/JIMMUNOL.1003446
Margareta Jernås, Intawat Nookaew, Hans Wadenvik, Bob Olsson, MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP) Blood. ,vol. 121, pp. 2095- 2098 ,(2013) , 10.1182/BLOOD-2012-12-471250
Fotios P. Panitsas, Maria Theodoropoulou, Alexandra Kouraklis, Marina Karakantza, Georgios L. Theodorou, Nicholas C. Zoumbos, Alice Maniatis, Athanasia Mouzaki, Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response Blood. ,vol. 103, pp. 2645- 2647 ,(2004) , 10.1182/BLOOD-2003-07-2268