Thrombolysis in children.

作者: Michael D. Williams

DOI: 10.1111/J.1365-2141.2009.07914.X

关键词: Intensive care medicineFibrinolysisHematologyThrombosisProspective cohort studyPost-thrombotic syndromeAdverse effectInternal medicineMedicineThrombolysisVascular occlusion

摘要: Thrombosis in children may result vascular occlusion and a potential loss of viability skin, limbs or organs, lead to the development post thrombotic syndrome. Thrombolysis prevent such complications, use thrombolytics has increased last three decades. Despite this, optimum paediatric treatment regimens for these drugs remain uncertain, accurate efficacy safety profiles are limited by lack controlled, prospective studies well-defined patient populations. Restoration vessel patency often been achieved but risk intracranial other major haemorrhage secondary thrombolysis continues be significant concern clinician deciding on treatment. This review summarises thrombolytic describes outcome data adverse events following treatment, as well limitations published thrombolysis.

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