Biochemical Mechanism of Alkylphosphonates
作者： Hong-Wu He , Hao Peng , Xiao-Song Tan
DOI: 10.1007/978-3-662-44431-3_7
关键词: Inhibitory postsynaptic potential 、 Biochemistry 、 Chemical modification 、 Thiamine pyrophosphate 、 Biochemical mechanism 、 Pig heart 、 Chemistry 、 Acetylphosphonate 、 Enzyme inhibition 、 Sodium
摘要: Alkylphosphonates Io were expected to be effective plant PDHc E1 inhibitors because they obtained by the chemical modification of sodium O-methyl acetylphosphonate as a hit compound, which is potent inhibitor. Therefore, it interesting examine inhibitory activity against E1. The biochemical mechanism was explored through method theoretical calculations and experiments. Several representative alkylphosphonates found powerful PDHc, but show no significant inhibition from pig heart. degree herbicidal these compounds positively correlated with their enzyme inhibition.
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