Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure.
作者： S. George , J.Y. Blay , P.G. Casali , A. Le Cesne , P. Stephenson
DOI: 10.1016/J.EJCA.2009.02.011
关键词: Survival rate 、 Internal medicine 、 Surgery 、 Adverse effect 、 Imatinib mesylate 、 Phases of clinical research 、 Gastroenterology 、 Sunitinib 、 Dosing 、 Medicine 、 Pharmacokinetics 、 Sunitinib malate
摘要: … Overall survival based on sKIT changes with continuous daily dosing of sunitinib. sKIT concentrations determined in plasma samples taken at baseline or on day 1 of treatment cycle 2 (A…
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Lesley J. Murray, Tinya J. Abrams, Kelly R. Long, Theresa J. Ngai, Lisa M. Olson, Weiru Hong, Paul K. Keast, Jacqueline A. Brassard, Anne Marie O'Farrell, Julie M. Cherrington, Nancy K. Pryer, SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model. Clinical & Experimental Metastasis. ,vol. 20, pp. 757- 766 ,(2003) , 10.1023/B:CLIN.0000006873.65590.68
Dong Wook Kim, Young Suk Jo, Hye Sook Jung, Hyo Kyun Chung, Jung Hun Song, Ki Cheol Park, Su Hyeon Park, Jung Hwan Hwang, So Young Rha, Gi Ryang Kweon, Su-Jae Lee, Ki-Won Jo, Minho Shong, An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases. The Journal of Clinical Endocrinology and Metabolism. ,vol. 91, pp. 4070- 4076 ,(2006) , 10.1210/JC.2005-2845
Anat Norden-Zfoni, Jayesh Desai, Judith Manola, Paul Beaudry, Jeremy Force, Robert Maki, Judah Folkman, Carlo Bello, Charles Baum, Sam E DePrimo, David R Shalinsky, Goerge D Demetri, John V Heymach, None, Blood-Based Biomarkers of SU11248 Activity and Clinical Outcome in Patients with Metastatic Imatinib-Resistant Gastrointestinal Stromal Tumor Clinical Cancer Research. ,vol. 13, pp. 2643- 2650 ,(2007) , 10.1158/1078-0432.CCR-06-0919
Elaine Wong, Lee S. Rosen, Marilyn Mulay, Andy VanVugt, Melissa Dinolfo, Chisato Tomoda, Masahiro Sugawara, Jerome M. Hershman, Sunitinib induces hypothyroidism in advanced cancer patients and may inhibit thyroid peroxidase activity. Thyroid. ,vol. 17, pp. 351- 355 ,(2007) , 10.1089/THY.2006.0308
Markku Miettinen, Jerzy Lasota, Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Archiv. ,vol. 438, pp. 1- 12 ,(2001) , 10.1007/S004280000338
Carlo L. Bello, Laurie Sherman, Jihao Zhou, Lev Verkh, John Smeraglia, Janessa Mount, Karen J. Klamerus, Effect of food on the pharmacokinetics of sunitinib malate (SU11248), a multi-targeted receptor tyrosine kinase inhibitor: results from a phase I study in healthy subjects. Anti-Cancer Drugs. ,vol. 17, pp. 353- 358 ,(2006) , 10.1097/00001813-200603000-00015
Jayesh Desai, Leila Yassa, Ellen Marqusee, Suzanne George, Mary C. Frates, Ming Hui Chen, Jeffrey A. Morgan, Samuel S. Dychter, P. Reed Larsen, George D. Demetri, Erik K. Alexander, Hypothyroidism after Sunitinib Treatment for Patients with Gastrointestinal Stromal Tumors Annals of Internal Medicine. ,vol. 145, pp. 660- 664 ,(2006) , 10.7326/0003-4819-145-9-200611070-00008
Christopher L. Corless, Jonathan A. Fletcher, Michael C. Heinrich, Biology of Gastrointestinal Stromal Tumors Journal of Clinical Oncology. ,vol. 22, pp. 3813- 3825 ,(2004) , 10.1200/JCO.2004.05.140
Christopher L. Corless, Arin Schroeder, Diana Griffith, Ajia Town, Laura McGreevey, Patina Harrell, Sharon Shiraga, Troy Bainbridge, Jason Morich, Michael C. Heinrich, PDGFRA Mutations in Gastrointestinal Stromal Tumors: Frequency, Spectrum and In Vitro Sensitivity to Imatinib Journal of Clinical Oncology. ,vol. 23, pp. 5357- 5364 ,(2005) , 10.1200/JCO.2005.14.068
Joshua Ö. Haznedar, Juthamas Sukbuntherng, Katherine G. Moss, Tinya J. Abrams, Julie M. Cherrington, Randall E. Schreck, Jeremy Carver, Cho Tang, Dirk B. Mendel, Gerald McMahon, James G. Christensen, Lesley J. Murray, Leslie B. Lee, Sharianne G. Louie, Emily Chan, Sheri Shirazian, Todd Miller, Guangmin Li, Theresa J. Ngai, Robert A. Blake, A. Douglas Laird, Xiaohua Xin, Li Sun, In Vivo Antitumor Activity of SU11248, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial Growth Factor and Platelet-derived Growth Factor Receptors Determination of a Pharmacokinetic/Pharmacodynamic Relationship Clinical Cancer Research. ,vol. 9, pp. 327- 337 ,(2003)