Evaluation of Portal Hemodynamics Using Indicator Dilution and Noninvasive Techniques

摘要: Microvascular exchange in the liver is quite peculiar owing to porosity of sinusoidal endothelial cells; pores endothelium allow free passage macromolecules, which allows hepatocyte take up tightly protein bound drugs (1). One major changes occurring cirrhosis capillarization (2), leads a profound impediment substances into space Disse. Sinusoidal was first described by Hans Popper on morphological level (2); he—rightfully—predicted that this phenomenon would have important bearings hepatic function. It lasted almost 20 yr until demonstrated functionally using multiple indicator dilution technique (3)—this study feat because it applied demanding humans before studying animal models. Another aspect altered microvascular loss fenestrations that, at least alcoholic disease, occurs significant fibrosis seen (4).