Post-infectious bronchiolitis obliterans and mannose-binding lectin insufficiency in Argentinean children.
作者： Verónica Giubergia , Maximiliano Salim , Jesica Fraga , Nicolás Castiglioni , Luisa Sen
DOI: 10.1111/RESP.12547
关键词: Disease 、 Mannan-binding lectin 、 Immunology 、 Bronchiolitis obliterans 、 Medicine 、 Genotype 、 Immune system 、 Population 、 Intensive care unit 、 Allele
摘要: Background and objective Post-infectious bronchiolitis obliterans (PIBO) is a severe disorder following acute lower pulmonary infection in young children, especially caused by adenovirus. Mannose-binding lectin (MBL) deficiency arising from polymorphisms the coding non-coding region on MBL2 gene has been associated with more frequent respiratory infections. Our aim was to evaluate influence of MBL variants susceptibility evolution children PIBO. Methods One hundred eleven PIBO diagnosis were studied. The A, B, D X promoter assessed PCR-RFLP. B alleles pooled as O. combined genotypes A/A YA/O grouped sufficient (sMBL), O/O XA/O insufficient (iMBL) groups. To frequency general population, we studied DNA samples 127 healthy donors blood bank hospital (control group). Results iMBL significantly compared controls (21.6% vs 10.2%, P = 0.01). patients iMBL required intensive care unit (P = 0.001) mechanical assistance at moment viral injury frequently than those sMBL. Conclusions Insufficiency common controls. This genetic condition initial disease, illustrating relevance innate immune defence factors prior maturation adaptative system.
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