Diacylglycerols: biomarkers of a sustained immune response in proteinopathies
作者： Paul L. Wood , Randall J. Woltjer
DOI: 10.1016/B978-0-12-815854-8.00016-1
关键词: Immune system 、 Immunology 、 Lipid biomarkers 、 Signal transduction 、 Medicine 、 Neuroinflammation 、 Phospholipases C 、 Dementia 、 Systemic inflammation
摘要: Abstract Proteinopathies, associated with the development of dementia, are characterized by both systemic inflammation and neuroinflammation. This sustained/unresolved immune response involves a large number inflammatory mediators that ultimately may be responsible for neuronal deficits underlie cognitive dysfunction. Our research others have demonstrated elevated levels diacylglycerols in brain plasma patients proteinopathies. We conclude these metabolic products phospholipases C D lipid biomarkers unresolved pathology. Since serve structural signal transduction roles, elevations normally tightly regulated lipids contribute to dysfunction
sci-hub.st 参考文章(37)
Mathieu P. Lichtenstein, Staging anti-inflammatory therapy in Alzheimer's disease. Frontiers in Aging Neuroscience. ,vol. 2, pp. 142- 142 ,(2010) , 10.3389/FNAGI.2010.00142
Lena Serrander, Maria F�llman, Olle Stendahl, Activation of phospholipase D is an early event in integrin-mediated signalling leading to phagocytosis in human neutrophils Inflammation. ,vol. 20, pp. 439- 450 ,(1996) , 10.1007/BF01486745
Raúl González-Domínguez, Tamara García-Barrera, José Luis Gómez-Ariza, Application of a novel metabolomic approach based on atmospheric pressure photoionization mass spectrometry using flow injection analysis for the study of Alzheimer's disease. Talanta. ,vol. 131, pp. 480- 489 ,(2015) , 10.1016/J.TALANTA.2014.07.075
Julie A. Wood, Paul L. Wood, Randall Ryan, Neill R. Graff-Radford, Carmencita Pilapil, Yves Robitaille, Remi Quirion, Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1β or IL-1RA but increases in the associated acute phase proteins IL-6, α2-macroglobulin and C-reactive protein Brain Research. ,vol. 629, pp. 245- 252 ,(1993) , 10.1016/0006-8993(93)91327-O
David A. Bennett, Douglas Galasko, John C. Morris, Jurg Ott, Patricia L. Kramer, Haiyan Xu, Randall L. Woltjer, Shawn K. Westaway, David Clark, Deniz Erten-Lyons, Jeffrey A. Kaye, Kathleen A. Welsh-Bohmer, Juan C. Troncoso, William R. Markesbery, Ronald C. Petersen, R. Scott Turner, Walter A. Kukull, Alzheimer Disease Pathology in Cognitively Healthy Elderly:A Genome-wide Study Neurobiology of Aging. ,vol. 32, pp. 2113- 2122 ,(2011) , 10.1016/J.NEUROBIOLAGING.2010.01.010
Robin B. Chan, Tiago G. Oliveira, Etty P. Cortes, Lawrence S. Honig, Karen E. Duff, Scott A. Small, Markus R. Wenk, Guanghou Shui, Gilbert Di Paolo, Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. Journal of Biological Chemistry. ,vol. 287, pp. 2678- 2688 ,(2012) , 10.1074/JBC.M111.274142
G. Zuliani, M. Ranzini, G. Guerra, L. Rossi, M.R. Munari, A. Zurlo, S. Volpato, A.R. Atti, A. Blè, R. Fellin, Plasma cytokines profile in older subjects with late onset Alzheimer's disease or vascular dementia. Journal of Psychiatric Research. ,vol. 41, pp. 686- 693 ,(2007) , 10.1016/J.JPSYCHIRES.2006.02.008
Jeffrey R. Crawford, Nicole L. Bjorklund, Giulio Taglialatela, Richard H. Gomer, Brain Serum Amyloid P Levels are Reduced in Individuals that Lack Dementia While Having Alzheimer’s Disease Neuropathology Neurochemical Research. ,vol. 37, pp. 795- 801 ,(2012) , 10.1007/S11064-011-0674-0
Daniel Schlam, Michal Bohdanowicz, Alexandros Chatilialoglu, Benjamin E. Steinberg, Takehiko Ueyama, Guangwei Du, Sergio Grinstein, Gregory D. Fairn, Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation. Journal of Biological Chemistry. ,vol. 288, pp. 23090- 23104 ,(2013) , 10.1074/JBC.M113.457606
S Shimohama, Y Sasaki, S Fujimoto, S Kamiya, T Taniguchi, T Takenawa, J Kimura, Phospholipase C isozymes in the human brain and their changes in Alzheimer's disease. Neuroscience. ,vol. 82, pp. 999- 1007 ,(1997) , 10.1016/S0306-4522(97)00342-4